2018-06-14 WP2 progress report

The Work Package 2 comprises the development of modified aptamers recognizing several important bacterial pathogens, the design and testing of model Autonomous Detection Nucleic Acids (AUDENAs) to achieve a pathogen detection tool with exchangeable specificity-determining unit. The tasks are handled by Austrian Institute of Technology (AIT) and Pure Biologics Inc. (PB, who replaced Apta Biosciences as the consortium partner in late 2017).
Recently, Pure Biologics has finished the first package of selections directed towards chosen bacterial targets and started another set of selections. The results are currently being analysed using Next Generation Sequencing techniques, which in conjunction with powerful bioinformatical analysis allow to readily identify multiple potential binders of the bacterial targets. Next, identified aptamers will be tested and optimized in order to incorporate them into working AUDENAs.
Parallelly, scientists at AIT have designed various AUDENA concepts and tested the new sensor class with previously published conventional DNA aptamers. With these experiments they could proof that the AUDENA technology can be used for the detection of bacterial antigens. A publication of the results in a scientific journal is planned in 2018 to demonstrate the usability of these cost-effective, stable and point-of-care compatible detection molecules.

Audena

2018-05-14 5th General Assembly Meeting

The 5th MARA project General Assembly meeting took place in Freibug on May 14th and 15th, 2018.

2018-03-20 New publication in Nanoscale

(Poly)cation-induced protection of conventional and wireframe DNA origami nanostructures.
Yasaman Ahmadi, Elisa De Llanoa, Ivan Barišić. Nanoscale. 2018 Apr 26;10(16):7494-7504.

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Polycarbonated

2017-12-30 Pure Biologics joins consortium

The Polish company Pure biologics joined the consortium in December 2017, as Apta Biosciences unfortunately left the project.

2017-12-19 4th General Assembly Meeting

The MARA project GA meeting took place in Vienna, on December 19th, 2017.
The next meeting will be in Freiburg on May 14th and 15th, 2018.

2017-08-29 New publication in IEEE Trans Vis Comput Graph

Multiscale Visualization and Scale-Adaptive Modification of DNA Nanostructures.
Miao H, De Llano E, Sorger J, Ahmadi Y, Kekic T, Isenberg T, Groller ME, Barisic I, Viola I. IEEE Trans Vis Comput Graph. 2018 Jan;24.

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Multiscale

2017-03-23 3rd General Assembly Meeting

The MARA project GA meeting took place in Aarhus, on May 23rd and 24th, 2017.

2016-06-02 2nd General Assembly Meeting

The MARA project General Assembly meeting took place in London, on June 2nd and 3rd, 2016.

2016-11-24 1st General Assembly Meeting

The 2nd MARA project General Assembly meeting took place in Slunj, on Nov 24th and 25th, 2016.

2016-03-30 News article

News article from Die Presse about the MARA project.

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2016-01-29 News article

News article from Die Presse about the MARA project.

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2016-01-29 News article

News article from Chemie report about the MARA project.

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2016-01-28 Very Important Business

MARA news on "Very Important Business".

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2016-01-28 Press release

MARA is in the news. Please click on the link to read the full press release.

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2015-11-10 Kickoff Meeting

The MARA project kick-off meeting took place in Vienna, Austria, on December 10th and 11th 2015.

2015-11-04 Apta Biosciences news

Apta Biosciences reports about the newly granted MARA project.

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