The Work Package 2 comprises the development of modified aptamers recognizing several important bacterial pathogens, the design and testing of model
Autonomous Detection Nucleic Acids (AUDENAs) to achieve a pathogen detection tool with exchangeable specificity-determining unit.
The tasks are handled by Austrian Institute of Technology (AIT) and Pure Biologics Inc. (PB, who replaced Apta Biosciences
as the consortium partner in late 2017).
Recently, Pure Biologics has finished the first package of selections directed towards chosen bacterial targets and started another set of selections. The results are currently being analysed using Next Generation Sequencing techniques, which in conjunction with powerful bioinformatical analysis allow to readily identify multiple potential binders of the bacterial targets. Next, identified aptamers will be tested and optimized in order to incorporate them into working AUDENAs.
Parallelly, scientists at AIT have designed various AUDENA concepts and tested the new sensor class with previously published conventional DNA aptamers. With these experiments they could proof that the AUDENA technology can be used for the detection of bacterial antigens. A publication of the results in a scientific journal is planned in 2018 to demonstrate the usability of these cost-effective, stable and point-of-care compatible detection molecules.
The 5th MARA project General Assembly meeting took place in Freibug on May 14th and 15th, 2018.
(Poly)cation-induced protection of conventional and wireframe DNA origami nanostructures.
Yasaman Ahmadi, Elisa De Llanoa, Ivan Barišić. Nanoscale. 2018 Apr 26;10(16):7494-7504.
The Polish company Pure biologics joined the consortium in December 2017, as Apta Biosciences unfortunately left the project.
The MARA project GA meeting took place in Vienna, on December 19th, 2017.
The next meeting will be in Freiburg on May 14th and 15th, 2018.
Multiscale Visualization and Scale-Adaptive Modification of DNA Nanostructures.
Miao H, De Llano E, Sorger J, Ahmadi Y, Kekic T, Isenberg T, Groller ME, Barisic I, Viola I. IEEE Trans Vis Comput Graph. 2018 Jan;24.
The MARA project GA meeting took place in Aarhus, on May 23rd and 24th, 2017.
The MARA project General Assembly meeting took place in London, on June 2nd and 3rd, 2016.
The 2nd MARA project General Assembly meeting took place in Slunj, on Nov 24th and 25th, 2016.
MARA news on "Very Important Business".
MARA is in the news. Please click on the link to read the full press release.
The MARA project kick-off meeting took place in Vienna, Austria, on December 10th and 11th 2015.
Apta Biosciences reports about the newly granted MARA project.